Drugs which people with Long QT Syndrome should avoid
Below is a list of the drugs that people with Long QT Syndrome should avoid. A similar list can also be found by clicking here.
Neither of these lists should be considered exhaustive, and you should always check with your GP and pharmacist if your doctor prescribes any new drugs for you, as these lists may not be complete.
* = Drugs which are unlicensed, withdrawn or suspended in the UK market
A - Z List
| Adrenaline (Epinephrine) | Stimulant | ||
| Ajmaline* | Antiarrhythmic (Class 1) | ||
| Alfuzosin | Alpha1-blocker | ||
| Almokalant* | Antiarrhythmic (Class 3) | ||
| Amantidine | Antimalarial | ||
| Amiodarone | Antiarrhythmic (Class 3) | ||
| Amitriptyline | Psychiatric drug - Tricyclic antidepressant | ||
| Amoxapine* | Psychiatric drug - Tricyclic antidepressant | ||
| Amphetamine | Stimulant | ||
| Arsenic trioxide | Anti-cancer | ||
| Astemizole* | Antihistamine | ||
| Atomoxetine | Psychiatric drug - Other | ||
| Azelastine | Antihistamine | ||
| Azimilide* | Antiarrhythmic (Class 3) | ||
| Azithromycin | Antibiotic - Macrolide | ||
| Bepridil* | Anti-anginal / vasodilator | ||
| Bretylium | Antiarrhythmic (Class 3) | ||
| Chloral hydrate | Sedative | ||
| Chloroquine | Antimalarial | ||
| Chlorpromazine | Psychiatric drug - Phenothiazine | ||
| Cibenzoline* | Antiarrhythmic (Class 1) | ||
| Ciprofloxacin | Antibiotic - Quinolone | ||
| Cisapride* | Serotonin agonist / antagonist | ||
| Citalopram | Psychiatric drug - Other | ||
| Clarithromycin | Antibiotic - Macrolide | ||
| Clobutinol* | Other | ||
| Clomipramine | Psychiatric drug - Tricyclic antidepressant | ||
| Clozapine | Anti-psychotic | ||
| Cocaine | Stimulant | ||
| Cold remedies | May contain stimulant drugs - always to check the label | ||
| Cotrimoxazole | Antibiotic - Antifungal | ||
| d-sotalol* | Antiarrhythmic (Class 3) | ||
| Desipramine* | Psychiatric drug - Tricyclic antidepressant | ||
| Dexmethylphenidate | Stimulant | ||
| Dihydroquinidine* | Antiarrhythmic (Class 1) | ||
| Diphenhydramine | Antihistamine | ||
| Disopyramide | Antiarrhythmic (Class 1) | ||
| Dobutamine | Stimulant | ||
| Dofetilide* | Antiarrhythmic (Class 3) | ||
| Dolasetron | Serotonin agonist / antagonist | ||
| Domperidone | Other | ||
| Dopamine | Stimulant | ||
| Doxepin | Psychiatric drug - Tricyclic antidepressant | ||
| Dronedarone* | Antiarrhythmic (Class 3) | ||
| Droperidol* | Psychiatric drug - Other | ||
| Ebastine* | Antihistamine | ||
| Encainide* | Antiarrhythmic (Class 1) | ||
| Ephedrine | Stimulant | ||
| Ersentilide* | Antiarrhythmic (Class 3) | ||
| Erythromycin | Antibiotic - Macrolide | ||
| Felbamate* | Anticonvulsant | ||
| Fenfluramine | Stimulant | ||
| Flecainide | Antiarrhythmic (Class 1) | ||
| Fluconazole | Antibiotic - Antifungal | ||
| Fluoxetine | Psychiatric drug - Other | ||
| Fluphenazine | Psychiatric drug - Phenothiazine | ||
| Foscarnet (HIV) | Antibiotics - Antiviral | ||
| Fosphenytoin (prodrug of Phenytoin) | Anticonvulsant | ||
| Galantamine | Inhibitor (dementia, Alzheimer's) | ||
| Gatifloxacin* | Antibiotic - Quinolone | ||
| Geldanamycin* | Anti-cancer | ||
| Gemifloxacin* | Antibiotic - Quinolone | ||
| Granisetron | Serotonin agonist / antagonist | ||
| Grepafloxacin* | Antibiotic - Quinolone | ||
| Halofantrine* | Antimalarial | ||
| Haloperidol | Psychiatric drug - Other | ||
| Hydroxyzine | Antihistamine | ||
| Ibutilide* | Antiarrhythmic (Class 3) | ||
| Imipramine | Psychiatric drug - Tricyclic antidepressant | ||
| Indapamide | Anti-hypertensive | ||
| Isoprenaline (Isoproterenol) | Stimulant | ||
| Isradipine | Anti-hypertensive | ||
| Itraconazole | Antibiotic - Antifungal | ||
| Ketanserin* | Serotonin agonist / antagonist | ||
| Ketoconazole | Antibiotic - Antifungal | ||
| Levalbuterol | Stimulant | ||
| Levofloxacin | Antibiotic - Quinolone | ||
| Levomethadyl* | Psychiatric drug - Other | ||
| Lidoflazine* | Anti-anginal / vasodilator | ||
| Lithium | Anti-mania | ||
| Maprotiline | Psychiatric drug - Other | ||
| Mesoridazine | Psychiatric drug - Other | ||
| Metaproterenol | Stimulant | ||
| Methadone | Psychiatric drug - Other | ||
| Methylphenidate | Stimulant | ||
| Mexiletine | Antiarrhythmic (Class 1) | ||
| Midodrine | Stimulant | ||
| Moexipril / Hydrochlorthiazide | Anti-hypertensive | ||
| Moxifloxacin | Antibiotic - Quinolone | ||
| Naratriptan | Anti-migraine | ||
| Nicardipine | Anti-hypertensive | ||
| Nifekalant* | Antiarrhythmic (Class 3) | ||
| Norepinephrine (Noradrenaline) | Stimulant | ||
| Nortriptyline | Psychiatric drug - Tricyclic antidepressant | ||
| Octreotide | Other | ||
| Ofloxacin | Antibiotic - Quinolone | ||
| Ondansetron | Serotonin agonist / antagonist | ||
| Organophosphates* | Other | ||
| Paroxetine | Anti-depressant | ||
| Pentamidine | Antibiotic - Other | ||
| Perflutren lipid microspheres | Other | ||
| Pericycline | Psychiatric drug - Other | ||
| Phentermine | Stimulant | ||
| Phenylephrine | Stimulant | ||
| Phenylpropanolamine | Stimulant | ||
| Pimozide | Psychiatric drug - Other | ||
| Pirmenol* | Antiarrhythmic (Class 1) | ||
| Prenylamine* | Anti-anginal / vasodilator | ||
| Probucol | Other | ||
| Procainamide | Antiarrhythmic (Class 1) | ||
| Prochlorperazine | Psychiatric drug - Phenothiazine | ||
| Propafenone | Antiarrhythmic (Class 1) | ||
| Protriptyline* | Psychiatric drug - Tricyclic antidepressant | ||
| Pseudoephidrine | Stimulant | ||
| Quetiapine | Psychiatric drug - Other | ||
| Quinidine* | Antiarrhythmic (Class 1) | ||
| Quinine | Antimalarial | ||
| Ranolazine | Anti-anginal / vasodilator | ||
| Risperidone | Psychiatric drug - Other | ||
| Ritodrine | Stimulant | ||
| Roxithromycin* | Antibiotic - Macrolide | ||
| Salbutamol (Albuterol) | Stimulant | ||
| Salmeterol | Stimulant | ||
| Sematilide* | Antiarrhythmic (Class 3) | ||
| Sertindole | Psychiatric drug - Other | ||
| Sertraline | Anti-depressant | ||
| Sibutramine | Stimulant | ||
| Solifenacin | Other | ||
| Sotalol | Antiarrhythmic (Class 3) | ||
| Sparfloxacin* | Antibiotic - Quinolone | ||
| Spiramycin | Antibiotic - Macrolide | ||
| Sumatriptan | Anti-migraine | ||
| Sunitib | Anti-cancer | ||
| Tacrolimus | Anti-cancer | ||
| Tamoxifen | Anti-cancer | ||
| Telithromycin | Antibiotic - Macrolide | ||
| Terbutaline | Stimulant | ||
| Terfenadine* | Antihistamine | ||
| Terikalant* | Antiarrhythmic (Class 3) | ||
| Terodiline* | Anti-anginal / vasodilator | ||
| Thioridazine* | Psychiatric drug - Phenothiazine | ||
| Tizanidine | Other | ||
| Tolterodine | Bladder antispasmodic | ||
| Trazodone | Psychiatric drug - Other | ||
| Trifluoperazine | Psychiatric drug - Phenothiazine | ||
| Trimethoprim sulfa (bactrim) | Antibiotic - Other | ||
| Trimipramine | Psychiatric drug - Tricyclic antidepressant | ||
| Vardenafil | Anti-anginal / vasodilator | ||
| Vasopressin | Other | ||
| Venlafaxine | Psychiatric drug - Other | ||
| Voriconazole | Antibiotic - Antifungal | ||
| Zimeldine* | Psychiatric drug - Other | ||
| Ziprasidone | Psychiatric drug - Other | ||
| Zolmitriptan | Anti-migraine |
Listed by type
Antiarrhythmics
Class 1: ajmaline*, cibenzoline*, dihydroquinidine*, disopyramide, encainide*, flecainide, mexiletine, pirmenol*, procainamide, propafenone quinidine*
Class 3: almokalant*, amiodarone, azimilide*, bretylium, dofetilide*, dronedarone*, d-sotalol*, ersentilide*, ibutilide*, nifekalant*, sematilide*, sotalol, terikalant*
Anti-anginals/vasodilators
bepridil*, lidoflazine*, prenylamine*, ranolazine, terodiline*, vardenafil
Anti-hypertensives
indapamide, isradipine, moexipril/hydrochlorthiazide, nicardipine
Antihistamines
astemizole*, azelastine, diphenhydramine, ebastine*, hydroxyzine, terfenadine*
Serotonin agonists and antagonists
cisapride*, dolasetron, granisetron, ketanserin*, ondansetron
Antimicrobials
Macrolide antibiotics: azithromycin, clarithromycin, erythromycin, roxithromycin*, spiramycin, telithromycin
Quinolone antibiotics: ciprofloxacin, gatifloxacin*, gemifloxacin*, grepafloxacin*, levofloxacin, moxifloxacin, ofloxacin, sparfloxacin*
Antifungals: cotrimoxazole, fluconazole (caution with itraconazole), ketoconazole, voriconazole
Others: pentamidine, trimethoprim sulfa (bactrim)
Antiviral: foscarnet (HIV)
Antimalarials
amantidine, chloroquine, halofantrine*, quinine
Psychiatric drugs
Tricyclic antidepressants: amitriptyline, amoxapine*, clomipramine, desipramine*, doxepin, imipramine, nortriptyline, protriptyline*, trimipramine
Phenothiazines: chlorpromazine, fluphenazine, prochlorperazine, thioridazine*, trifluoperazine
Others: atomoxetine, citalopram, clozapine, droperidol*, fluoxetine, haloperidol, levomethadyl*, lithium, maprotiline, mesoridazine, methadone, paroxetine, pericycline, pimozide, quetiapine, risperidone, sertindole, sertraline, trazodone, venlafaxine, zimeldine*, ziprasidone
Anticonvulsant
felbamate*, fosphenytoin (prodrug of phenytoin)
Anti-migraine
naratriptan, sumatriptan, zolmitriptan
Anti-cancer
arsenic trioxide, geldanamycin*, sunitib, tacrolimus, tamoxifen
Others
alfuzosin, chloral hydrate, clobutinol*, domperidone, galantamine, octreotide, organophosphates*, perflutren lipid microspheres, probucol, solifenacin, tizanidine, tolterodine, vasopressin
Stimulant drugs
Some cold remedies contain these drugs so it is important always to check the label.
adrenaline (epinephrine), amphetamine, cocaine, dexmethylphenidate, dobutamine, dopamine, ephedrine, fenfluramine, isoprenaline (isoproterenol), levalbuterol, metaproterenol, methylphenidate, midodrine, norepinephrine (noradrenaline), phentermine, phenylephrine, phenylpropanolamine, pseudoephidrine, ritodrine, salbutamol (albuterol), salmeterol, sibutramine, terbutaline
Source: Sads.org.uk
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