2 sets of patients:
1. ALI/ARDS and everything else
2. Obstructive (COPD/Asthma)
Mode
= when not sure use A/C
= you set the TV and RR
= patient initiates, and machine gives preset of Vt eg 500c
4 things you have to know about ALI (ARDSnet)
Vt = lung protection; 6-8 cc/kg IBW
Flow rate = patient comfort
RR = ventilation
FiO2/PEEP = Oxygenation
Vt = PROTECTION
- goal is to lower to 6cc/kg
- not adjusted according to ventilation (eg CO2 of 60, don't increase Vt or if low, don't lower Vt)
Inspiratory flow rate/IFR/peak flow = COMFORT
- how quickly a breath is delivered
- if high breath duration is quick
- 60-80 lpm
- if patient is sucking, not getting enough air = increase IFR
RR = VENTILATION
- 60 cc/kg/min to maintain eucapnia
- once intubated, requirement doubles due to deadspace of the circuit -> 120 cc/kg/min
70 x 120 = 8400
8400cc/500cc = 17
therefore start 16-18/min to prevent hypercapnia
- if hyperventilating, go down; if hypoventilating CO2 is low, RR to go up
* for acidotic patients, needs high minute ventilation
minimum 240 cc/kg/min, at least 36/min and adjust up
to prevent hypercapnia, to prevent acidosis
FiO2/PEEP =OXYGENATION
- if low O2, increase FiO2/PEEP tandem
- start 100% FiO2, wait x 5 minutes, get ABG
- drop to 40%, after 2 minutes wait for result
- use the PEEP scale for PEEP/FiO2, target 90-95% saturation (not more than >95%, at saturation of 100%, you won't know if the PaO2 is 80% or 400% which is too much), adjust every 10 minutes
- PEEP does not pop lungs!

PEEP
- good: Improves V/Q, decreases shunt, decreases atelectasis/trauma, improves spont breathing
- bad: decreases venous return (you can work it out, give more fluid)
- myth: causes pneumothorax, head explodes
*alveoli is like balloon: easier to blow if there's some air already in there
How to avoid pneumothorax
- check plateau pressure (or alveolar pressure), should be <30cmH20
- check every 30 minutes, if >30, adjust PROTECTION which is Vt (if too high drop Vt from 8 to 7)
- peak pressure means nothing

Ventilation curve pattern/ventilation pressure wave form on VC mode
- air rushes to ET tube, tracheobronchial tree = high initial pressure = Peak pressure
- after system has equilibrated with alveolar, it plateaus = Plateau pressure
Peak pressure: PIP/Peak Inspiratory pressure
- means nothing to patient's safety
- does not affect the alveoli
- only purpose is to alarm the vent
Plateau pressure:
- this reflects small airway and alveolar pressure
- not measured by vent directly (after delivering the oxygen, vent drops very quickly)
- should be less than 30cmH20
- press inspiratory hold button (0.5-1 second) once patient breathes = plateau pressure
*Peak pressure: pressure on major airways (+ ET tube) = alarm
Plateau pressure: pressure on smaller airways (+ alveoli) = matters
PIP: peak airway pressure
Pplat: Plateau pressure
Paw: airway pressure
SUMMARY:
Vt: if plateau pressure >30, decrease Vt
IFR/Peak flow: if patient is sucking, not getting enough air = increase IFR
RR = ventilation, if CO2 too high, increase RR
FiO2/PEEP: increase this if <90% saturation with target 90-95%
analgesia:
- fentanyl or morphine
- comfort for pain, blunts effects of hypercapnia
then sedation:
- propofol, ativan, versed
OBSTRUCTION (asthma, COPD)
- goal: give patients time to expire
- mode: AC
Vt: 8cc/kg IBW
IFR/peak flow: make inspiration shorter therefore higher to expire slower: 80-100 lpm
FiO2: 40-100%, usually no Oxygenation problem, leave at 40% if you want (they desaturate because they tire out)
PEEP: zero
RR: - most important setting, set this low
- start at 10
IE ratio: 1:4 or 1:5
Permissive Hypercapnia
- CO2 of >50, as long as pH is 7.2, 7.1 (because of hypercapnia) that's fine
- bicarb has no pathophysiologic reason
AVOID air-trapping and autoPEEP
- air trapping: alveoli are closed off cuz of mucous plugging and air could not go out, needs suctioning/pulmonary toilet
- auto PEEP: dynamic overinflation of alveoli, goes away if they are allowed to breathe

Airtrapping: normally there is a space between fully expiring gas and the next inspiration
in obstructive disease, the air is not fully exhaled and inspiration comes in immediately, stacking air/gas
- if this happens, lower RR
AutoPEEP
- if vent doesnt have this, look at plateau pressure
*peak pressure
- does not mean anything
- represents ET tube, large airways
- constricted on obstructive disease, therefore this is high like 80-90, therefore this always alarms, just increase upper treshold of alarm, cuz this does not mean anything
* plateau pressure: if >30, significant auto PEEP, decrease RR
if <30, autoPEEP is not significant
Scenario
- Asthmatic, crashing on the vent (low sat low BP)
DISCONNECT the vent, leave the ET tube
- if air rushes, the air-stacked will go out
- if no air rush, no improvement of vital signs = use DOPE
Sedated completely (you intubated this patients due to muscle fatigue, so dont let them breathe)
- propofol: has bronchodilatory effect too
analgesia: fentanyl/morphine; blunts hypercapnia, for comfort
SUMMARY:
Vt: 8cc/kg
IFR: 80lpm
FiO2: just maintain sats >90
RR: 10
- if airtrapping on curve, decrease down to 8 to 6
- if >30 plateau pressure; down RR
-----
pdf Vent Handout from Dr Scott Weingart
Crashing post intubation
D - isplacement
O - osbstruction
P - PTX
E - Equipment failure
S - in asthma, stacked breaths
Stacked breaths - disconnect the vent circuit
- if air gushes out, patient improves
- if no improvement, no air gushing = proceed to DOPS
Equipment failure - attached BVM (eg kinked tube, machine failure, no O2 in vent etc)
D - tube Displacement: check ETCO2 colorimetric or wave form
O - obstruction: suction, if too thick plug, can push with bougie, but the plug will go deeper
P - tension PTX, check with US if with time, otherwise....
Perform bilateral finger thoracostomies!!!
Level of ET tube: from teeth, Caucasian 23 M, 21 F; Asian 22 M, 20 F
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