Monday, June 6, 2011

CDR Contents

CDR/Clinical Decision Rules Guides
Computations, Others



Computations/Numbers: convert US to SI units

  • Anion Gap = Na - (Cl + HCO3) = 8-16. If you have lactate value, you can subtract it from AG. eg. if AG = 16 and lactate is 6, then AG is 10 which is normal and no need to further look for mudpiles
  • Corr. AG = AG + 0.25 x (40-Alb). Low albumin leads to underestimation of AG if not corr.
  • Corrected Sodium: Corrected sodium ( mmol/L ) = measured Na + 2 x (plasma glucose - 5.6 ) 5.6 due to translational hyponatremia; high glucose leads to shift of water from ICF to ECF diluting and decreasing the sodium 1.6 mEq/L for every 100mg/dL (5.6 mmol/L) of glucose. Na corrects itself once glucose level is corrected. This formula actually underestimates sodium level.
  • Urea/Crea = prerenal if >0.1 (intrinsic if less)
  • Serum Osmolality = 2*Na + urea + glucose + ethanol (optional); 280-295
  • Osmolal Gap = meas. osm - calc. osm; ≤10 normal. Unmeasured osmotically active substance include methanol, mannitol, ethyl glycol, sorbitol (MMES)
  • HHS: glucose >33.3, pH >7.3, HCO3 >15, osmolality >320 mOsm/kg
  • DKA: glucose >11, pH <7.3, HCO3 <15, ketonuria or ketonemia
  • Mild DKA, pH/HCO3 <7.3/18; moderate DKA <7.25/15; severe DKA <7/10 link




Bleeding GIT

Stable: suspected of Melena/hematochezia/hematemesis
Hx:
  • Hx of Bleeding GIT (Endoscopy/Colonoscopy)
  • EtOH
  • Meds: Aspirin/Plavix/Warfarin/other anticoagulants/NSAID/TCM/Steroid
  • Cocaine/Sympathomimetics: ulcer
  • Pain/No pain doesn't correlate with endoscope
  • Hx of liver disease/heart failure
PE
  • Abdominal exam
  • Cirrhosis
  • Rectal: look for fissures/hemorrhoids/anoscope
Labs
  • ECG if anemic
  • FBC/PT/Urea/Type and screen
  • NG aspirate and lavage in ED: low sensitivity for hematochezia/melena (without hematemesis); Academic Emergency Medicine Feb 2010
  • No imaging
*80% will need rebleed, only 20% needs to catch, but this patients are those with liver disease, on steroids, etc

Screening/Scoring = Non variceal bleeding: All common sense
- Blatchford score, Modified Glasgow Blatchford score, Rockall, Lee

* assume it's upper always: more common, more commonly fatal, you can do something
* assume it's variceal (not ulcer)
* if unstable, NG tube always! varices are not contraindicated

Corrected sodium underestimates sodium

Hyperglycemia lowers serum sodium levels; the degree to which has been updated from the previous dogma of:

Conventional Units: For each 100 mg/dL (over 100 mg/dL) the blood glucose rises; the measured serum sodium should have 1.6 mEq/L added to it in order to correct for the effect of the hyperglycemia.

SI Units: For each 5.6 mmol/L (over 5.6 mmol/L) the blood glucose rises; the measured serum sodium should have 1.6 mmol/L added to it in order to correct for the effect of the hyperglycemia.

In an interesting trial where the effects of hyperglycemia on sodium levels were actually measured, Hillier, et al. demonstrate that the correction factor of 1.6 is inaccurate and leads to serious underestimation of serum sodium levels; especially in those patients with blood glucose concentrations of >500 mg/dL. The clinical information from this; study, is that a factor of 2.4 is more appropriate.

We are now utilizing the 2.4 adjustment factor. The formulas for each are below:

Conventional Units:
Glucose = mg/dL Sodium = mEq/L For each 100 mg/dL (greater than 100 mg/dL) the blood glucose rises; the measured serum sodium should have 2.4 mEq/L added to it in order to correct for the effect of the hyperglycemia.

  • Corrected Serum Sodium = Measured Serum Sodium + [(Glucose measured - 100)/100]x2.4

SI Units: For each 5.6 mmol/L (greater than 5.6 mmol/L) the blood glucose rises; the measured serum sodium should have 2.4 mmol/L added to it in order to correct for the effect of the hyperglycemia.

  • Corrected Serum Sodium = Measured Serum Sodium + [(Glucose measured - 5.6)/5.6]x2.4

Reference:
Hillier TA, et al. Hyponatremia; evaluating the correction factor for hyperglycemia. Am J Med April 1999;106:399-403. Huffman, GB. Adjusting Sodium Levels in Patients with Hyperglycemia. Am Fam Phy. 15 October 1999;60(6):1798.

Bleeding GIT


  • for suspected bleeding, can give 40mg IV omeprazole or esomeprazole while waiting for labs, confirming with rectal exam as long as hemodynamically stable
  • For active bleeding: 80mg IV then 8mg/hr infusion
  • Variceal bleed: Somatostatin 250mcg IV then 250mcg/hr infusion x 5 days -- inhibits vasodilatory hormone like glucagon, indirectly causing splanchnic vasoconstriction and decreased portal inflow.
  • others: vasopressin (0.4 U bolus then 0.4 to 1 U/min infusion) or ocreotide - a long-acting somatostatin analog (50mcg then 50mcg/h). Somatostatin is the most superior among the three
  • Antibiotics for variceal bleeding
  • Maintain Hb to 8 g/dL
Unstable
  • Airway: Supplemental oxygen, intubate early
  • FFP: known liver disease, don't wait for PT/PTT
  • Platelets if indicated
  • DDAVP: if renal failure
  • PCC:
  • Factor VIIa:
1. Sengstaken-Blakemore: gastric balloon, esophageal balloon, gastric suction port
2. Minnesota: plus esophageal suction port
3. Linton: single gastric balloon, most effective

Lower GI
- Diverticular bleeding, Angiodysplasia
- IR, GS

Sunday, June 5, 2011

Anti-emetics

1. Metoclopramide 10mg IV/IM/PO
2. Prochlorperazine (Stemetil): 5, 10mg PO 12.5mg IM
3. Ondansetron (Zofran): 4, 8mg IM IV (PO 8-16mg prior to chemo)
4. Droperidol: 0.625-1.25 mg IM/IV, rule out long QT first

Others:
Antihistamines
1. Promethazine (Phenergan): 12.5-25mg PO/IM/IV
2. Diphenhydramine

Friday, June 3, 2011

03 Ventilator

Ventilator
1. Mode
2. Setting

DOPE (displaced tube, obstructed tube, pneumothorax, equipment failure)

Mechanical Ventilation:
Modes:
1. AC (assist control): volume control
- Assist: patient triggers (vent assists)
- Control: apneic (vent controls)
- preset tidal volume or peak pressure is delivered
- if peak pressure is used, then it’s called IPPV (Intermittent Positive Pressure Ventilation) but initiation timing is the same
- you set RR and TV and that’s what the patient gets; if patient is unconscious, then the machine will give you this rate and volume; if patient decides to breathe, then they initiate the breath and the machine does all the work (patient is work-free)
- this is probably the only mode we use in ED which is for ALI or ventilatory problems – unless we tube for protection of airway where the lungs are fine, then you can use other modes
- least work of breathing although can overventilate (tachypnea)

2. SIMV (Spontaneous Intermittent Mandatory Mode)
- more work of breathing, ventilator delivers Vt/pressure dependent on patient’s effort and not fixed like AC
3. PS (Pressure support)
- needs spontaneous breathing, once triggered, vent gives pressure to help patient draw in Vt
4. SIMV with PS
- SIMV with extra boost of pressure support to get in more Vt (not dependent on patient’s effort)
5. CPAP
- spontaneously breathing; analogous with PEEP
- constantly on selected pressure
6. CPAP with PS
- BiPAP on a vent
- decreased work of breathing compared to CPAP alone
7. Controlled Mechanical Ventilation (CMV).
- ventilator provides a mechanical breath on a preset timing, Patient respiratory efforts are ignored
- uncomfortable

Oxylog 3000 Modes:
IPPV/IPPVAssist
- IPPV is for apneic patient, IPPVAssist synchronizes on partially breathing patients; IPPA Assist is automatically activated if Trigger is activated to have a value (small value = high sensitivity)
- Intermittent Positive Pressure Ventilation
- Controlled and assisted volume-constant ventilation with PEEP for CPPV
SIMV/ASB
- Synchronized Intermitted Mandatory Ventilation
- Assisted spontaneous breathing
- Procedure for weaning patients off the ventilator after they have started spontaneous breathing, with adjustable pressure assist during spontaneous breathing
CPAP/ASB
- Continuous positive airway pressure
- Spontaneous breathing with positive airway pressure and adjustable pressure assist
BIPAP/ASB
- Biphasic Positive Airway Pressure
- Pressure-controlled ventilation combined with free spontaneous breathing during the complete breathing cycle, and ajustable pressure assisted on CPAP level

4 Dials 70kg
VT 500
RR 18
Pmax: maximum airway pressure; peak pressure, this is the alarm limit 50mbar
FiO2 100%


Peak pressure
- topmost pressure after inspiration
- pressures on upper/major airways and ET tube
- does not mean anything

Plateau pressure (link)
- after peak pressure, tell the ventilator don’t allow the patient to exhale = inspiratory hold (0.5-1 second), don’t allow expiratory airflow = all the pressures along ventilatory circuit equalizes = what pressure the vent sees is the same as the pressure in the alveoli = plateau pressure
- pressure along lower airways/alveoli, maintained <30cmh2o cstat=" Vt/Pplat" cstat =" Static" vt =" tidal" pplat =" Peak" peep =" Positive" name="Title" content="">

2 Strategies (you ventilate 2 groups of patient) in ED
1. Lung injury or prone to it, or
2. Obstruction like asthma/COPD

Things to remember: use predicted body weight PBW
1. Mode
2. Numbers
(1) TV (Vt) = 6-8 cc/kg;protection

- should not be adjusted for ventilation (not to adjust pCO2)
- ALI/ARDS: 6 cc/kg
- adjusted only to prevent baro/volutrauma
(2) IFR: inspiratory flow rate 60-80 lpm comfort
- controls how quickly air goes in

- this can affect I:E ratio
(eg. for high Vt, I:E ratio should be 1:2, but in bronchoconstriction, it’s less than <1:2, rr =" ventilation
- on normal TV non-intubated: Va (alveolar ventilation) is 60cc/kg/min to maintain normal pCO2
- when tubed and ventilated, Va is doubled up to 120 cc/kg/min because of increased dead space (machine circuit and tube itself steals the volume away, so minute ventilation should be higher)
--
eg. 70kg patient, what is the minute ventilation?
70 x 120 = 8400 or 9000 cc/min
If you set Vt at 500 cc (which is 70kg x 7cc/kg)
how much should be your RR? = 18
therefore, normally ventilated 70kg should have
Vt = 500cc
RR = 18

- if RR is lower, say 10, minute volume decreaseds= hypercapnia since less pCO2 is released


*minute ventilation (respiratory minute volume) = TV x RR
*minute ventilation (V) = Va + dead space ventilation (Vd)
V
- volume of air that can be inhaled or exhaled per minute
- normal: 5-8L/min
- higher V higher pCO2 is released and vice versa

*adjust RR for ventilation where you want your pCO2, you can make RR to 30 or 40 unless it’s obstructive

Male: 50 + 0.91 (cm of height – 152.4)

Famale: 45.5 + 0.91 (cm of height – 152.4)

Males: 50 + 2.3 (height (in) – 60)

Females: 45.5 + 2.3 (height (in) – 60)
(4) FiO2/PEEP = oxygenation
- start 100% FiO2 and PEEP of 5, after 5 minutes get ABG
- down 40%
- adjust with PEEP scale
- target 88-95% saturation (make it 90%)

Lower PEEP/higher FiO2

FiO2 0.3 0.4 0.4 0.5 0.5 0.6 0.7 0.7

PEEP 5 5 8 8 10 10 10 12

FiO2 0.7 0.8 0.9 0.9 0.9 1.0

PEEP 14 14 14 16 18 18-24


--

Problems on Mechanical ventilation:
1. Too high Vt = overdistended = PTX
2. Shunt but PEEP is not increased:
*If saturation is <90% fio2 =" shunt"> shunt does not respond to more oxygen because the alveoli are collapsing (fills with fluid) -> more lung injury
*PEEP scale forces the alveoli from collapsing during expiration, alveoli stay more open and easier to oxygenate
*FiO2 more than 40% does not really help unless you bump up the PEEP

Plateau pressure:
- to make sure patient is safe in ventilator
- pressure applied on smaller airways and alveoli = can cause ventilator induced lung injury
- should be <30cmh20 style="">Peak pressure:
- pressure on major upper airways, ET tube = airway resistance
- does not mean anything

- in obstructive disease, this could be very high but it does not matter as it does not affect the alveoli

Opioid: Fentanyl or Morphine
1. Analgesia: tube is shoved in your throat
2. Blunts hypercapnia
Sedation:
- after opioid is given
- benzo or propofol (so you’re patient won’t remember these)

Obstructive Setting: Asthma/COPD

Goal is to give as much expiratory time as possible
Use large ET tube (8 Fr)

Mode-Assist Control

Vt-8 cc/kg by PBW

IFR-80-100 lpm (shortens inspiration, more time to exhale)

PEEP-0

FiO2-use whatever you need, most folks are fine at 40% (unless there is something else like pneumonia)

RR-Start at 10 bpm. Look for I:E of 1:4 or 1:5 Adjust the rate to achieve this.

Permissive Hypercapnia

Patients will need tons of sedation/opioids

Keep pH above 7.1; rarely, you may need a bicarb drip to accomplish this
Don’t adjust RR, don’t adjust Vt; get permissive hypercapnia instead of airtrapping, autoPEEP



FiO2
PEEP
RR

Oxylog 3000


Asthma
AC (Assist Control) volume

TV: 8mL/kg
higher IFR (inspiratory flow rate): 80L/min
FiO2: 40%
PEEP: 0
RR (most important): start at zero
*plateau pressure

Arrest Ventilated COPD/Asthma
1. Disconnect from ventilator
2. External compress x 1
- if no improvement
3. Bilateral needle thoracostomy, bedside U/S if you have time
- check the rest of DOPE
- Displaced = EtCO2
- Obstructed = sucker
- Equipment failure = bag
4. Fluids 2L (they are dehydrated)

PEEP (positive end expiratory pressure)
- especially in low Vt, at the end of expiration, the lower/distal airways/alveoli collapses, PEEP prevents it by acting like a ”stent”
AutoPEEP
- problem in AC, tachypneic or those with reduced expiratory airflow may not have enough time to exhale the large Vt = the air the remains in the alveoli at the end of expiration creates PEEP or auto PEEP = impair cardiac output or causes barotrauma
- decreasing Vt may help but will not completely cure it
IMV: Intermittent Mandatory Ventilation
- invented (1971) to counter problems with AC
- originally for neonates with RR of 40/min and has RDS
- combination of AC + spontaneous respiration
Permissive Hypercapnia:

- low Vt prevents VILI but low Vt accumulates CO2


Qualitative ETCO2:


- purple to yellow (litmus paper)


- pearls:


1. should be after 6 breaths (swallowed CO2 in the stomach)


2. not reliable in vomiting patient (litmus paper is affected)

3. not reliable in epinephrine via ET tube (again, litmus paper)


4. not reliable in cardiac arrest (could not measure low CO2), in this case quantitative ETCO2 is needed to see wave form

Anaphylaxis

Criteria: Acute onset (minutes to hours)
Criterion 1 (90% of cases)
- skin +/- mucosa plus respi +/- decreased BP (or symptoms: syncope/dizziness)
Criterion 2 (10-20%)
- any 2: skin/mucosa, respi, decreased BP or symptoms, persistent GI (vomit/diarrhea/cramps)
Criterion 3
- decreased BP after exposure (<90 or more than 30% from baseline)


1. Airway: O2, consider intubation if airway oedema
- consider albuterol from bronchospasm
2. Adrenaline: 0.3-0.5mL (0.3-0.5mg) 1:1,000 q 5-15 mins
+/- infusion 1:10,000 2-10mcg/min

- Peds: 0.01 mg/kg/dose IM (Max: 0.5mg)
or
>12: 0.5mg
6-12: 0.3mg
<6: 0.15
Infusion: 0.05-1 mcg/kg/min

3. Normal Saline
2L bolus (20mL/kg for peds)

4. Antihistamines: pruritus control
- AFTER hemodynamically stable; choices:
a. Chlorpheniramine IM or slow IV
>12: 10mg
6-12: 5mg
6m-6y: 2.5mg
<6m: 250mcg/kg

b. Promethazine 25 IM or slow IV
c. Diphenhydratmine 25-50mg IM or slow IV

5. Hydrocortisone IM or slow IV: may blunt biphasic reaction
>12: 200mg
6-12: 100mg
6m-6y: 50mg
<6m: 25mg
* 3 days PO (biphasic reaction always occurs within 72 hours)

or Methylprednisolone
- 125mg IV (2mg/kg in peds)

Cure


Anaphylaxis

Thursday, June 2, 2011

NEXUS

Inclusion: Alert, Not intoxicated, No distracting injury

No focal neuro deficit
No posterior midline c spine tenderness

-> no need to image the c spine

--
Ann Emerg Med. 1998 Oct;32(4):461-9

Canadian CT Head Rule

mild head injury within 24 hours
inclusion: minor HI (defined as GCS 13-15, with LOC, Amnesia, or disorientation/LAD)
this is just a guide logic says that it excludes: those who had seizures, on anticoagulants, etc

1. High Risk (for neurological intervention)

- GCS <15 at 2 hours post-injury

- ≥ vomits

- ≥ 65

- Signs of Basal skull # (raccoon eyes, battle's sign, hemotympanum, csf otorrhoea, csf rhinorrhoea)

- suspected open or depressed skull # (clinical not xray)

2. Medium Risk (for brain injury on CT)

- amnesia before impact >30 minutes

- dangerous mechanism (pedestrian vs motor vehicle, ejected, fall from height >3 feet or 5 stairs)


--
Lancet. 2001 May 5;357(9266):1391-6





CHADS2 Score

CHF = 1 pt
Hypertension = 1pt
Age ≥75 = 1pt
DM = 1pt
(Prior) Stroke or TIA = 1pt

0 = 1.9%/year
1 = 2.8%
2 = 4%
3 = 5.9%
4 = 8.5%
5 = 12.5%
6 = 18.2%


CHADS2 estimates risk of ischemic stroke for those with nonrheumatic Af
Generally, oral anticoagulation is strongly advised with score ≥2

--
JAMA. 2001 Jun 13;285(22):2864-70

Canadian C-spine Rule


1. Inclusion
- trauma, GCS 15, Stable VS, Age ≥16

2. Exclusion
- Acute paralysis, Known vertebral disease, Previous C-spine surgery

3. Any high-risk factors which mandate radiography? If yes = image
- 65yo, Paraesthesia in extremities, Dangerous mechanism*

4. Any low-risk factors which allow safe assessment of range of motion? If no = image
- Simple rearend MVC **, sitting in ED, ambulatory at any time, delayed onset of neck pain, absence of midline c-spine tenderness

5. Assessment of Range of Motion. If no = image
- Able to actively rotate neck 45 degrees L and R

*Fall from >1m / 5 stairs
Axial load to head, eg diving
MVC high speed (>100 km/hr, rollover, ejection)
Motorized recreational vehicles
Bicycle struck or collision

**Pushed into oncoming traffic
Hit by bus/large truck
rollover
hit by high speed vehicle
None of the above

-> CCR is for alert, stable patients with trauma to safely reduce rate of C spine radiography

--
JAMA. 2001 Oct 17;286(15):1841-8.





Wednesday, May 11, 2011

PE

Massive
  • Sustained hypotension
(<90 SBP x 15 minutes or inotrope use)
  • Pulselessness
  • Persistent Profound Bradycardia
(<40 bpm with s/s shock)
Submassive: RV dysfunction or Myocardial necrosis
Acute PE without hypotension but with:
RV dysfunction:
  • RV dilatation RV:LV diameter >0.9 in A4C/CT or RV systolic dysfxn in echo
  • BNP >90 pg/mL or NT pro BNP >500
  • ECG: (new RBBB, anteroseptal STE, STD or TWI)
Myc Necrosis: TnI >0.4ng/mL, TnT >0.1

Low-risk PE: not massive, not submassive

Massive: heparin + alteplase (100mg x 2 hrs IV or in cardiac arrest: 50mg IV bolus then another 50mg IV bolus after 15 mins if no ROSC)

Submassive: heparin +/- alteplase
*alteplase if shock/respiratory distress or mod-severe respiratory distress
shock or respiratory distress
  • <90mmHg
  • SI >1
  • SaO2 <95% with Borg score >8
  • AMS
  • appearance of suffering
mod-severe respiratory distress
  • RV hypokinesis, interventricular septal shift or bowing, or est. RVSP >40 mmHg
  • clearly elevated cardiac markers
, TnT above borderline, BNP >100 pg/mL or NTpBNP >900
Low-risk: clexane 1mg/kg or heparin

Thrombolysis c/i:
Absolute c/i
- prior ICH
- known intracranial CVD (AVM)
- known malignant IC neoplasm
- ischaemic stroke within 3 months
- suspected aortic dissection
- active bleeding or bleeding diathesis
- recent surgery encroaching on spinal canal or brain
- recent significant closed-head or facial trauma with radiographic evidence of bony fracture or bony injury

Relative c/i
>75yo
- use of anticoagulation
- pregnancy
- non compressible vascular punctures
- traumatic or prolonged CPR (>10 minutes)
- recent internal bleeding (within 2-4 weeks)
- hx of chronic, severe, and poorly controlled HTN
- severe uncontrolled HTN on presentation >180/>110)
- dementia
- remote (>3 months) ischaemic stroke


- major surgery within 3 weeks

Friday, March 11, 2011

Approach

AMS
Bleeding GI
Chest Pain in the Young
Dizziness and Giddiness
Electrolytes
Headache
Shoulder Dystocia
Status Epilepticus
Valvular Emergencies
Toxicology

Ortho
Injury = Neurovascular complication